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expand all sections collapse all sections Oryza sativa (indica cultivar-group) protein "Q2XPP5" (Autophagy 8)
Accession Q2XPP5
Species Oryza sativa (indica cultivar-group) [ GR_tax:013682 ]
Name Autophagy 8
Symbol APG8
Synonyms (0)
E.C. Numbers (0) None
Gene Names (1) Atg8 (Autophagy 8)
Organelle Not available
Best Hits To TIGR Rice Gene Models (0) None  [ Click here to generate a BLASTP query ]
IRGSP/RAP Genes (0) None
Source TREMBL
GenBank Accessions (1) ABB77258
UniProt Accession (Sequence) Q2XPP5
Cultivar Zhenxian 97B ( GRIN , IRIS )
Comment
Autophagy pathway is a highly regulated process for bulk degradation of proteins and organelles. It has been shown to be essential for differentiation, development and cellular maintenance. ATG8 is an essential protein in the autophagic pathway and undergoes post-translational modification including the C-terminal cleavage. The protein is covalently conjugated to phosphatidylethanolamine (PE) and localizes to autophagosome membranes, which promotes the formation of autophagosome and their delivery to the vacuole for subsequent degradation. Mutation analysis revealed that the conserved Gly117 residue of ATG8 was essential for its characteristic C-terminal cleavage. Protein encoded by another gene Autophagy 4 (Atg4, GR:0101172) interacts with the ATG8 and is involved in its post-translational modification. It is an ortholog of Arabidopsis thaliana gene APG8A/ATG8A (AT4G21980).
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