biological_process Term "I-kappaB kinase/NF-kappaB cascade" (GO:0007249)

Term Name	I-kappaB kinase/NF-kappaB cascade
Term Accession	GO:0007249
Aspect	biological_process
Synonyms (4)	activation of the inhibitor of kappa kinase, canonical NF-kappaB signaling cascade, NF-kappaB cascade, p50-dependent NF-kappaB signaling
Definition	The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database