cellular_component Term "aminoacyl-tRNA synthetase multienzyme complex" (GO:0017101)

Term Name	aminoacyl-tRNA synthetase multienzyme complex
Term Accession	GO:0017101
Aspect	cellular_component
Synonyms (2)	aminoacyl-tRNA synthetase complex, multisynthetase complex
Definition	A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database