molecular_function Term "dihydrofolate reductase activity" (GO:0004146)

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molecular_function Term "dihydrofolate reductase activity" (GO:0004146)

Term Name	dihydrofolate reductase activity
Term Accession	GO:0004146
Aspect	molecular_function
Synonyms (13)	5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity, 7,8-dihydrofolate reductase activity, DHFR, dihydrofolate reductase:thymidylate synthase activity, dihydrofolate reduction, dihydrofolic acid reductase activity, dihydrofolic reductase activity, folic acid reductase activity, folic reductase activity, NADPH-dihydrofolate reductase activity, pteridine reductase:dihydrofolate reductase activity, tetrahydrofolate dehydrogenase activity, thymidylate synthetase-dihydrofolate reductase activity
Definition	Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database

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Derivation

molecular_function (GO:0003674) #8429

[i] catalytic activity (GO:0003824) #33842

[i] oxidoreductase activity (GO:0016491) #27384

[i] oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645) #0

[i] oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646) #0

[i] dihydrofolate reductase activity (GO:0004146) #61

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Database Cross-References (6)

EC:	1.5.1.3
EC:	1.5.1.3
MetaCyc:	DIHYDROFOLATEREDUCT-RXN
Reactome:	REACT_111041
Reactome:	REACT_115762
RHEA:	15012

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Parents (1)

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)

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Children (0)

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Associations (61)

Arabidopsis lyrata gene (3)

Arabidopsis thaliana gene (3)

Brachypodium distachyon gene (1)

Brassica rapa gene (5)

Chlamydomonas reinhardtii gene (1)

Cyanidioschyzon merolae gene (1)

Glycine max gene (4)

Hordeum vulgare gene (1)

Medicago truncatula gene (10)

Musa acuminata gene (1)

Oryza brachyantha gene (2)

Oryza glaberrima gene (2)

Oryza sativa indica gene (4)

Oryza sativa japonica gene (2)

Physcomitrella patens gene (1)

Populus trichocarpa gene (4)

Selaginella moellendorffii gene (2)

Setaria italica gene (2)

Solanum lycopersicum gene (1)

Solanum tuberosum gene (1)

Sorghum bicolor gene (1)

Vitis vinifera gene (3)

Zea mays gene (4)

Gramene Gene (2)