molecular_function Term "cholesterol 24-hydroxylase activity" (GO:0033781)

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molecular_function Term "cholesterol 24-hydroxylase activity" (GO:0033781)

Term Name	cholesterol 24-hydroxylase activity
Term Accession	GO:0033781
Aspect	molecular_function
Synonyms (6)	cholesterol 24-monooxygenase activity, cholesterol 24S-hydroxylase activity, cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity, CYP46, CYP46A1, cytochrome P450 46A1
Definition	Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database

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Derivation

molecular_function (GO:0003674) #8429

[i] catalytic activity (GO:0003824) #33842

[i] oxidoreductase activity (GO:0016491) #27384

[i] monooxygenase activity (GO:0004497) #5935

[i] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709) #100

[i] cholesterol 24-hydroxylase activity (GO:0033781) #0

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Database Cross-References (15)

EC:	1.14.13.98
EC:	1.14.13.98
RHEA:	22719
RHEA:	22719
KEGG:	R07207
MetaCyc:	1.14.13.98-RXN
Reactome:	REACT_100868
Reactome:	REACT_10129
Reactome:	REACT_102867
Reactome:	REACT_78490
Reactome:	REACT_79067
Reactome:	REACT_79090
Reactome:	REACT_79585
Reactome:	REACT_83550
Reactome:	REACT_94780

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Parents (1)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)

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