biological_process Term "reductive tricarboxylic acid cycle" (GO:0019643)

Term Name	reductive tricarboxylic acid cycle
Term Accession	GO:0019643
Aspect	biological_process
Synonyms (6)	GO:0019644, reductive carboxylate cycle, reductive carboxylic acid cycle, reductive citric acid pathway, reductive Kreb's cycle, reductive TCA cycle
Definition	A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
Comment	None
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