molecular_function Term "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" (GO:0001209)

Term Name	metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
Term Accession	GO:0001209
Aspect	molecular_function
Synonyms (0)	None.
Definition	Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database