molecular_function Term "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" (GO:0001204)

Term Name	metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
Term Accession	GO:0001204
Aspect	molecular_function
Synonyms (0)	None.
Definition	Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
Comment	None
Source Ontology Database	The GO browser of Gene Ontology Database