Reference "The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003"

Reference ID

7915

Title

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

Source

Nucleic acids research, 2003, vol. 31, pp. 365-370

Authors (12)

Boeckmann-B	Bairoch-A	Apweiler-R	Blatter-M-C
Estreicher-A	Gasteiger-E	Martin-M-J	Michoud-K
O'Donovan-C	Phan-I	Pilbout-S	Schneider-M

Abstract

The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and
http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current
knowledge in the Life Sciences. Each protein entry provides an interdisciplinary
overview of relevant information by bringing together experimental results,
computed features and sometimes even contradictory conclusions. Detailed
expertise that goes beyond the scope of SWISS-PROT is made available via direct
links to specialised databases. SWISS-PROT provides annotated entries for all
species, but concentrates on the annotation of entries from human (the HPI
project) and other model organisms to ensure the presence of high quality
annotation for representative members of all protein families. Part of the
annotation can be transferred to other family members, as is already done for
microbes by the High-quality Automated and Manual Annotation of microbial
Proteomes (HAMAP) project. Protein families and groups of proteins are regularly
reviewed to keep up with current scientific findings. Complementarily, TrEMBL
strives to comprise all protein sequences that are not yet represented in SWISS-
PROT, by incorporating a perpetually increasing level of mostly automated
annotation. Researchers are welcome to contribute their knowledge to the
scientific community by submitting relevant findings to SWISS-PROT at swiss-
prot@expasy.org.