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expand all sections collapse all sections Oryza sativa gene "MEL1" (GR:0080042)
Species Oryza sativa (Rice) [ GR_tax:013681 ]
Accession GR:0080042
Gene Symbol MEL1
Gene Name MEL1 
Synonyms (7)
E.C. Numbers (0)
Pathway Reactions (0)
Chromosome No. 3
Gene Type CDS (Protein coding)
Has Phenotype yes
Description Rice AGO gene MEIOSIS ARRESTED AT LEPTOTENE1 (MEL1) was identified from the analysis of seed-sterile mutants. In the mel1 mutant, chromosome condensation was arrested at early meiotic stages and irregularly sized, multinucleated, and vacuolated pollen mother cells (PMCs) frequently appeared in developing anthers. In addition, histone H3 lysine-9 dimethylation of pericentromeres was rarely reduced and modification of the nucleolar-organizing region was altered in mel1 mutant PMCs. The mutation also affected female germ cell development. These results indicate that the germ cell–specific rice MEL1 gene regulates the cell division of premeiotic germ cells, the proper modification of meiotic chromosomes, and the faithful progression of meiosis, probably via small RNA–mediated gene silencing, but not the initiation and establishment of germ cells themselves.
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toggle section Associated Ontologies (28)
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toggle section SNPs (49)